PTENtiating autoimmunity through Treg cell deregulation
نویسندگان
چکیده
منابع مشابه
The Balance of Th17 versus Treg Cells in Autoimmunity
T helper type 17 (Th17) cells and pTreg cells, which share a common precursor cell (the naïve CD4 T cell), require a common tumor growth factor (TGF)-β signal for initial differentiation. However, terminally differentiated cells fulfill opposite functions: Th17 cells cause autoimmunity and inflammation, whereas Treg cells inhibit these phenomena and maintain immune homeostasis. Thus, unraveling...
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The molecular mechanisms that govern differential T cell development into pro-inflammatory Th17 vs. regulatory T (Treg) cells remain unclear. Here, we show that selective deletion of CREB in T cells or Th17 cells impaired Th17 cell differentiation in vitro and in vivo, and led to resistance to autoimmune diseases. Mechanistically, CREB, activated by CD3-PKC-ϴ signaling, plays a key role in regu...
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2015
ISSN: 1529-2908,1529-2916
DOI: 10.1038/ni.3082